Adult Stem Cells Treatments

Researchers using induced pluripotent stem cells, inject the stem cells into animal hearts which then promotes a level of restoration in functionality on their subjects…

Science Daily

“University of Cincinnati researchers have found that applying a stem cell-infused patch together with overexpression of a specific cell instruction molecule promoted cell migration to damaged cardiac tissue following heart attack and resulted in improved function in animal models.”

“Three days following the heart attack, researchers placed a cell patch on the damaged region and measured the expression of cardiac-related transcription factor A (a protein that binds to specific DNA sequences, controlling the movement of genetic information from DNA to mRNA), collagen levels in the damaged tissue andscar formation-related signaling pathways.”

Research starting to focus more on the bilical cord which according to the article is not very well understood because of the lack of research in this area of stem cells. A team of researchers from Peking University People’s Hospital, China, decided to conduct a study.

Physorg and their researchers paper is found here

“The researchers took immune cells from RA patients and showed that the umbilical MSCs were able to suppress the cells’ proliferation, invasive behavior and inflammatory responses. Systemic infusion of the umbilical MSCs into mice was shown to significantly reduce the severity of collagen-induced arthritis. Speaking about the results, Professor Li said, “RA imparts a massive burden on health services worldwide and none of the currently used agents reaches long term drug-free remission. Therefore, a new and more effective therapy for RA will be very welcome”.

Great news concerning stem cells obtained from umbilical cords which may be used to treat rheumatoid arthritis! And that’s not all, those of us who like to workout notice a breakdown in function and mass as we get older. However, research in adult stem cells of transplanted into the leg muscles of mice restored function and mass in their muscles. Now wouldn’t it be great to maintain muscle function and mass as you get older? The finding may lead to treatments for patients with chronic, degenerative muscle diseases…

“The experiments showed that when young host mice with limb muscle injuries were injected with muscle stem cells from young donor mice, the cells not only repaired the injury within days, they caused the treated muscle to double in mass and sustain itself through the lifetime of the transplanted mice. “This was a very exciting and unexpected result,” said Professor Bradley Olwin of CU-Boulder’s molecular, cellular and developmental biology department, the study’s corresponding author.”

When a cardiovascular disease gets so serious, the only option left is amputation of a limb. This has happened to one of my grandparents. But today, a treatment was announced that may save many thousands of limbs from amputation!

Science daily reports…

“Northwestern Medicine physician researchers are revolutionizing treatment of cardiovascular disease by utilizing patients’ own stem cells to regenerate heart and vascular tissue. Northwestern Medicine is the lead site for a study examining stem cell transplantation as treatment for critical limb ischemia.”

“Stem cell treatment was associated with a significant reduction in amputation rate,” said Losordo. “Treatment was associated with a 50 percent reduction in the total amputation rate compared to control. Although further study is needed, these results provide evidence that CD34 cell therapy is an effective treatment for critical limb ischemia.”

What about Embryonic Stem Cell research? After all, nature lobbied congress to hurry and pass laws to fund this research in fear of Republicans getting elected. All the hype since 2000 on this research has produced this recently…

In science daily, “Growing human embryonic stem cells in the lab is no small feat.”

In Nature, the news was nothing more than some research in Singapore trying to identify all the transcription factors that regulate embryonic stem cells.

Nothing about treatments of animals nor humans which is not surprising. The explosion of new treatments is coming from adult stem cells which is where the funding should be provided. Something that ES proponents never dreamed could happen because they thought it would mostly come form ES. Speaking of which why aren’t they rejoicing in all these advances in adult stem cell research?   


Major Progress For Adult Stem Cell’s Future Treatments

Research conducted by Derrick Rossi at Boston’s Children Hospital had a huge breakthrough.  By programming an RNA messenger (mRNA) a certain way, they can safely insert genetic switches into a cell without changing the DNA with virus vectors! PhysOrg said that these induced pluripotent stem cells (iPSC) are “apparently identical to human embryonic stem cells, the initial building blocks of all the organs of the body.”

This solves not one major problem but all three problems since induced pluripotent stems were discovered back in 2007.  Shinya Yamanaka deserves a Noble Prize for his discovery and the progress made by Rossi is simply, “awesome” and perhaps he too in the future deserves a Nobel Prize!

“Because the mRNA carries genetic instructions, but does not enter the DNA of the target cells, the resulting tailored cells should be safe to use in treating patients, Rossi said, unlike the iPS cells now being created around the world.

“Our findings address three major impediments to clinical translational use of iPS cells,” Rossi said in an interview. “The method: does not in any way breach genomic integrity as it does not necessitate integrating genes or viruses into the target cells’ DNA; it is orders of magnitude more efficient at producing iPS cells than conventional iPS methods, which were notoriously inefficient; and it gives us a way to directly program and direct the fate (development) of the iPS cells towards clinically useful cell types.”

This is not the only breakthrough happening in adult stem cell research, recently there were some researchers at the Royal Prince Alfred Hospital and the University of Sydney that “found a way to increase the number of blood-forming stem cells when growing them outside of the body.”

Physorg reports…

“By using a unique stretchy surface that allows the cells to pull on it, the researchers found they could generate up to three times more stem cells than using current methods alone. Published today in the leading biotechnology journal Nature Biotechnology, lead author Professor John Rasko from the Centenary Institute and RPA Hospital announced these findings could significantly improve the outcomes of stem cell transplants.”

Huge breakthrough here because the more that can be grown in the lab, the less they have to harvest from the body like umbilical cords, bone marrow, and other areas and thus, the more patients can benefit!  On another breakthrough this time coming from the University of Buffalo, researchers have found a way to keep adult stem cells from aging!

In science daily

“UB scientists created the new cell lines — named “MSC Universal” — by genetically altering mesenchymal stem cells, which are found in bone marrow and can differentiate into cell types including bone, cartilage, muscle, fat, and beta-pancreatic islet cells. The researchers say the breakthrough overcomes a frustrating barrier to progress in the field of regenerative medicine: The difficulty of growing adult stem cells for clinical applications.”

This discovery could help speed up the development of cost-effective treatments for diseases including heart disease, diabetes, immune disorders and neurodegenerative diseases! Also, lowering costs of stem cell therapies and being able to produce individually-tailored cell lines. And finally this latest breakthrough adult stem cell research “electrified the field,” because of the new ability to reprogram adult stem cells to behave just like embryonic stem cells!

This is great science! A science who’s research is not getting more complex with fifty different explanations due to falsifications in the data that in itself is mere speculation while many of them cannot be tested nor verified. But in instead this research is producing a better understanding for the improvement of mankind!

Because the mRNA carries , but does not enter the DNA of the target cells, the resulting tailored cells should be safe to use in treating patients, Rossi said, unlike the iPS cells now being created around the world.“Our findings address three major impediments to clinical translational use of iPS cells,” Rossi said in an interview. “The method: does not in any way breach genomic integrity as it does not necessitate integrating genes or viruses into the target cells’ DNA; it is orders of magnitude more efficient at producing iPS cells than conventional iPS methods, which were notoriously inefficient; and it gives us a way to directly program and direct the fate (development) of the iPS cells towards clinically useful cell types.”