Major Progress For Adult Stem Cell’s Future Treatments

Research conducted by Derrick Rossi at Boston’s Children Hospital had a huge breakthrough.  By programming an RNA messenger (mRNA) a certain way, they can safely insert genetic switches into a cell without changing the DNA with virus vectors! PhysOrg said that these induced pluripotent stem cells (iPSC) are “apparently identical to human embryonic stem cells, the initial building blocks of all the organs of the body.”

This solves not one major problem but all three problems since induced pluripotent stems were discovered back in 2007.  Shinya Yamanaka deserves a Noble Prize for his discovery and the progress made by Rossi is simply, “awesome” and perhaps he too in the future deserves a Nobel Prize!

“Because the mRNA carries genetic instructions, but does not enter the DNA of the target cells, the resulting tailored cells should be safe to use in treating patients, Rossi said, unlike the iPS cells now being created around the world.

“Our findings address three major impediments to clinical translational use of iPS cells,” Rossi said in an interview. “The method: does not in any way breach genomic integrity as it does not necessitate integrating genes or viruses into the target cells’ DNA; it is orders of magnitude more efficient at producing iPS cells than conventional iPS methods, which were notoriously inefficient; and it gives us a way to directly program and direct the fate (development) of the iPS cells towards clinically useful cell types.”

This is not the only breakthrough happening in adult stem cell research, recently there were some researchers at the Royal Prince Alfred Hospital and the University of Sydney that “found a way to increase the number of blood-forming stem cells when growing them outside of the body.”

Physorg reports…

“By using a unique stretchy surface that allows the cells to pull on it, the researchers found they could generate up to three times more stem cells than using current methods alone. Published today in the leading biotechnology journal Nature Biotechnology, lead author Professor John Rasko from the Centenary Institute and RPA Hospital announced these findings could significantly improve the outcomes of stem cell transplants.”

Huge breakthrough here because the more that can be grown in the lab, the less they have to harvest from the body like umbilical cords, bone marrow, and other areas and thus, the more patients can benefit!  On another breakthrough this time coming from the University of Buffalo, researchers have found a way to keep adult stem cells from aging!

In science daily

“UB scientists created the new cell lines — named “MSC Universal” — by genetically altering mesenchymal stem cells, which are found in bone marrow and can differentiate into cell types including bone, cartilage, muscle, fat, and beta-pancreatic islet cells. The researchers say the breakthrough overcomes a frustrating barrier to progress in the field of regenerative medicine: The difficulty of growing adult stem cells for clinical applications.”

This discovery could help speed up the development of cost-effective treatments for diseases including heart disease, diabetes, immune disorders and neurodegenerative diseases! Also, lowering costs of stem cell therapies and being able to produce individually-tailored cell lines. And finally this latest breakthrough adult stem cell research “electrified the field,” because of the new ability to reprogram adult stem cells to behave just like embryonic stem cells!

This is great science! A science who’s research is not getting more complex with fifty different explanations due to falsifications in the data that in itself is mere speculation while many of them cannot be tested nor verified. But in instead this research is producing a better understanding for the improvement of mankind!

Because the mRNA carries , but does not enter the DNA of the target cells, the resulting tailored cells should be safe to use in treating patients, Rossi said, unlike the iPS cells now being created around the world.“Our findings address three major impediments to clinical translational use of iPS cells,” Rossi said in an interview. “The method: does not in any way breach genomic integrity as it does not necessitate integrating genes or viruses into the target cells’ DNA; it is orders of magnitude more efficient at producing iPS cells than conventional iPS methods, which were notoriously inefficient; and it gives us a way to directly program and direct the fate (development) of the iPS cells towards clinically useful cell types.”

Why Are Some Scientists Obsessed with ESC Research?

While adult stem cell research continues to show promise in various treatments, we find some scientists who are obsessed with keeping embryonic stem cell research on the public dole. The same tactics are used in their argument which are also used in the creationism vs. evolution debate. For example, some have claimed, restricting funding on ESC research is an attack on “science” despite the fact that $500 million already has been spent on ESC research.

Jack Mosher at the University of Michigan said, “It’s worrying that I could come into work one day and I might not be allowed to do my research because of someone’s ideological beliefs rather than the quality of the science.” Many specular promises are made for what might come out of the research. Last month Nature published a article critical of adult stem cells suggesting that some may have memory problems making  true pluripotent stem cells and ESC more appealing.

Nature news in a court ruling against funding ESC research are lobbying congress to make a law to keep taxpayer money coming in while awaiting another decision by the court. Physorg has been the only secular outlet that has a balanced story on the advancements of adult stem cell research and ESC research. The article notes the ethical concerns with embryonic stem cell research unlike previous articles in other publications.

Dr. Paul Sanberg, admitted that “Two decades of cell-based research has been accompanied by poor management of public discussion regarding ethics.” That is because for many of them who are pro-ESC research, it’s not about ethics or the fact that adult stem cells have been showing greater promise in treatments but it’s about the money!

It has been reported that a spinal cord treatment using embryonic stem cells is going to be conducted for the first time on humans but no amount of scientific research on embryos can address the ethics of doing what they can do. The destruction of a human embryo! However, not all of this research is bad, there are other ways of obtaining ESC that can be used for treatments without ethical concerns but one thing is for sure, ESC research is not going to live up to the hype that some scientists are suggesting  with their obsession using emotional ranting, hopefully this is not going to take away from adult stem research and it’s progress!  The United States is for the people and by the people and the public should not bow down to scientists and always give them what they want, they are only human!

Dental Pulp Stem Cells Could Be Good For the Brain

Adult stems cells have been found to regenerate many different types of cells. In this new discovery, scientists have found a unique feature in dental stem cells which can stimulate growth of new neural cells, and many of these formed neurons.

Since Obama started running for office up until now where he promised to unban embryonic stem cells research, the focus has been on one aspect of this type of cell research. While very little attention has been paid to the major progress of adult stem cells. You can talk to a person on the street about stem cells and generally what the first thing comes to mind are embryonic stem cells. I believe the general public is not aware enough about this vital research concerning adult stem cells.

The conflict with embryonic stem cells, has created a political circus. Generally, collecting human embryonic stem cells for the most part come from embryos. Once the cells are collected, it then destroys the remaining embryo. There is an alternative in collecting these type of cells, but not enough to satisfy the demand. There is currently a shortage of human embryonic stem cells which can result in paying people to obtain them.

As far as Christians are concern, the embryos are human life no question about it, no science to refute otherwise on when life begins, but to liberals embryos are just a “thing” to work with while promising to find cures for diseases.

Back to the latest discovery of the promising possible impact of dental pulp stem cells which are adult stems cells…

By showing dental pulp stem cells are capable of stimulating growth of neurons, our study demonstrates the specific therapeutic potential of dental pulp stem cells and the broader potential for adult stem cells,” says Chan, who also is assistant professor of human genetics in Emory School of Medicine.

“Because dental pulp stem cells can be isolated from anyone at any age during a visit to the dentist, Chan is interested in the possibility of dental pulp stem cell banking. “Being able to use your own stem cells for therapy would greatly decrease the risk of cell rejection that we now experience in transplant medicine,” says Chan” -Science Daily

Adult stem cells show way more promise and it’s way more versatile. It’s also humane, and helps decreasing cell rejection. You can make a cell regenerate but if it’s rejected, it’s no use to the person who needs treatment. Very exciting to learn about the progress in dental pulp stem cell research, thanks to the Lord!

Embryonic Stem-cell Law Goes To the Polls

In Michigan on November 4, voters will be going to the polls not only to elect a new President, but also vote on embryonic stem-cell research…

“Proposal 2 would add a constitutional amendment allowing embryonic stem cell research to the Michigan Constitution. The amendment would also prevent state and local regulation.

The proposal is aimed at overturning a 1978 Michigan law that criminalizes the use of embryos for research and is one of the five most restrictive in the nation. The 20-year-old law has effectively discouraged life-science research in the state.”

This means lawmakers wouldn’t be able to make laws restricting embryonic research, it would give proponents of this particular research a free reign. Concerns have surface over this issue including the business aspect of it…

Obviously the most important aspect of this proposal is not the free reign or possible corporations profiting by the proposal if passed, it’s human life. Generally the argument goes, the embryonic stem cells scientists want to use will be just thrown away so why not use them? These types of stems cells can be collected by other means. Two wrongs, don’t make a right.

“The initiative has “major significance” because presidential candidates John McCain and Barack Obama have both hinted that, if elected, they would loosen federal restrictions on embryonic stem-cell research, says Stephen Rapundalo, executive director of MichBio in Ann Arbor, a non-profit organization trying to drive growth of the life-sciences industry in the state” Nature

Much attention has been focused on Gov. Palin’s position on this type of research in which she opposes, but on the other hand, Sen. McCain is more in favor of allowing this type of stem cell research to expand. I would recommend Michigan voters to vote “no” on this proposal.

In England, it’s been a major issue as well. The House of Commons in that country after a bitter debate approved a law that would allow the use of animal-human hybrids for stem-cell research.

“Researchers are allowed to inject empty cow or rabbit eggs with human DNA and apply a burst of electricity to trigger the regular cell division that forms embryos. They then hope to harvest stem cells, after which the embryos will be destroyed.

“Scientists say the embryos would not be allowed to develop for more than 14 days and are intended to address the shortage of human eggs available for stem-cell research,” the Associated Press reported.” ICR

As highlighted in this blog with documented research, adult stem cells has shown tremendous progress and also shows more promise of treatments than embryonic stem cell research. McCain and Obama are wrong  and should not loosen restrictions on the embryo which is human life.