Major Progress For Adult Stem Cell’s Future Treatments

Research conducted by Derrick Rossi at Boston’s Children Hospital had a huge breakthrough.  By programming an RNA messenger (mRNA) a certain way, they can safely insert genetic switches into a cell without changing the DNA with virus vectors! PhysOrg said that these induced pluripotent stem cells (iPSC) are “apparently identical to human embryonic stem cells, the initial building blocks of all the organs of the body.”

This solves not one major problem but all three problems since induced pluripotent stems were discovered back in 2007.  Shinya Yamanaka deserves a Noble Prize for his discovery and the progress made by Rossi is simply, “awesome” and perhaps he too in the future deserves a Nobel Prize!

“Because the mRNA carries genetic instructions, but does not enter the DNA of the target cells, the resulting tailored cells should be safe to use in treating patients, Rossi said, unlike the iPS cells now being created around the world.

“Our findings address three major impediments to clinical translational use of iPS cells,” Rossi said in an interview. “The method: does not in any way breach genomic integrity as it does not necessitate integrating genes or viruses into the target cells’ DNA; it is orders of magnitude more efficient at producing iPS cells than conventional iPS methods, which were notoriously inefficient; and it gives us a way to directly program and direct the fate (development) of the iPS cells towards clinically useful cell types.”

This is not the only breakthrough happening in adult stem cell research, recently there were some researchers at the Royal Prince Alfred Hospital and the University of Sydney that “found a way to increase the number of blood-forming stem cells when growing them outside of the body.”

Physorg reports…

“By using a unique stretchy surface that allows the cells to pull on it, the researchers found they could generate up to three times more stem cells than using current methods alone. Published today in the leading biotechnology journal Nature Biotechnology, lead author Professor John Rasko from the Centenary Institute and RPA Hospital announced these findings could significantly improve the outcomes of stem cell transplants.”

Huge breakthrough here because the more that can be grown in the lab, the less they have to harvest from the body like umbilical cords, bone marrow, and other areas and thus, the more patients can benefit!  On another breakthrough this time coming from the University of Buffalo, researchers have found a way to keep adult stem cells from aging!

In science daily

“UB scientists created the new cell lines — named “MSC Universal” — by genetically altering mesenchymal stem cells, which are found in bone marrow and can differentiate into cell types including bone, cartilage, muscle, fat, and beta-pancreatic islet cells. The researchers say the breakthrough overcomes a frustrating barrier to progress in the field of regenerative medicine: The difficulty of growing adult stem cells for clinical applications.”

This discovery could help speed up the development of cost-effective treatments for diseases including heart disease, diabetes, immune disorders and neurodegenerative diseases! Also, lowering costs of stem cell therapies and being able to produce individually-tailored cell lines. And finally this latest breakthrough adult stem cell research “electrified the field,” because of the new ability to reprogram adult stem cells to behave just like embryonic stem cells!

This is great science! A science who’s research is not getting more complex with fifty different explanations due to falsifications in the data that in itself is mere speculation while many of them cannot be tested nor verified. But in instead this research is producing a better understanding for the improvement of mankind!

Because the mRNA carries , but does not enter the DNA of the target cells, the resulting tailored cells should be safe to use in treating patients, Rossi said, unlike the iPS cells now being created around the world.“Our findings address three major impediments to clinical translational use of iPS cells,” Rossi said in an interview. “The method: does not in any way breach genomic integrity as it does not necessitate integrating genes or viruses into the target cells’ DNA; it is orders of magnitude more efficient at producing iPS cells than conventional iPS methods, which were notoriously inefficient; and it gives us a way to directly program and direct the fate (development) of the iPS cells towards clinically useful cell types.”

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2 thoughts on “Major Progress For Adult Stem Cell’s Future Treatments

  1. Shinya Yamanaka deserves a Noble Prize for his discovery….

    Here we have another indication of how much Michael knows about science. It’s Nobel prize, Michael. NOBEL, not Noble.[1] But then, Michael has not, 8 months after his challenge, vouchsafed to his readers his qualifications to report on any field of science. Or anything else, for that matter.[2]

    We may suppose the reason Michael is so enamored of this new research is that he thinks it will obviate the need for embryonic stem cells. His memory is apparently too short to recall that the judicial interdiction of embryonic stem-cell research also INTERRUPTED 80% OF THE U.S. RESEARCH ON ADULT STEM CELLS.

    Everyone hopes that adult stem cells will pan out. Even apart from the ethical questions, adult cells are easier to come by. They can be immunologically matched to the person who receives the treatment. And, as an added bonus, they enable anyone to clone himself, not just a select few.

    Without reading the actual papers, it’s difficult to assess how significant this work is, in terms of the ultimate goals. I would bet, however, that the significance is less than portrayed in the popular press. Michael may wish to look back on any one of a dozen “major advances” in adult stem cells that he has breathlessly reported in the past year.

    This is another misconception that creationists suffer from–the breakthrough mentality. That all we need is a single finding, that just one piece will make all the pieces fit into place. This mistake is allied with the misconception that we should search for “the” cure for cancer, or “the” ultimate elementary particle. In reality, science progresses along numerous fronts, a little at a time—you might even say that it evolves in a Darwinian fashion.

    It does seem ironic that creationists, who denigrate most scientific findings, should turn around and idolize science in this way. But then, no one has ever thought that creationists are rational.

    ============

    [1] Michael probably didn’t notice that one of this year’s Nobel prizewinners also did win the Noble prize—the Ig Noble prize, awarded for “research that cannot or should not be reproduced.” Yes, Andre Geim won a 2010 Nobel prize for his co-discovery of graphene, and had earlier won a 2002 Ig Noble prize for magnetically levitating a frog.

    [2] Nor has he offered his long-promised substantive review of Signature in the Cell. Has he found this project too far beyond his qualifications? (See the previous question, above.)

  2. Doctors administered millions of potentially life-saving embryonic stem cells into a partially paralyzed patient in Atlanta, making today a significant day in the advancement of stem cell research.

    The patient, whose identification remains confidential, is being treated for a spinal cord injury and is now at the Shepherd Center in Atlanta, which specializes in brain and spinal cord injuries, for rehabilitation.

    Many are surprised that Atlanta was chosen for this procedure, considering that there have been legislative proposals to ban stem cell research. However, Atlanta has upheld their reputation for cutting-edge research in spinal-cord injuries.

    “This clinical trial represents another step forward in Shepherd Center’s involvement in an attempt to find a cure for paralysis in people with spinal cord injury,” Dr. David Apple, the center leader for the stem cell procedure, said in a statement.

    Embryonic stem cells are still the gold standard, leading the way for the adult induced cells that we all hope will follow. But they are not there yet.

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