Coming out of the ribosome are chains of amino acids, they fold into these three-dimensional structures where the protein takes on a major role in the life of a cell. However, a small percentage is so complex that it requires help in order to fold correctly. Designed GroEL+GroES enzymes allows these types of proteins to fold privately in a space which holds 60,000 atomic mass units in size. Next, a designed “chaperone” device plays a vital role by enhancing the speed by 10 when the folding takes place otherwise it might fall into a “kinetic trap” which could cause major damage within the cell.
“Bacterial cells generally contain multiple, partly redundant chaperone systems that function in preventing the aggregation of newly synthesized and stress-denatured proteins,” the authors said. “In contrast to all other components of this chaperone network, the chaperonin, GroEL, and its cofactor, GroES, are uniquely essential, forming a specialized nano-compartment for single protein molecules to fold in isolation.” –Cell
Scientists at Rice University have been trying to model protein folding on computers. The scientists make an interesting observation, they say, that “Protein folding is regarded as one of the biggest unsolved problems in biophysics.” The mystery consists of proteins finding their native fold through a maze of wrong folds but somehow it’s accomplished very quickly! But once done, these folded proteins are the workhorses in the cell, performing all kinds of specialized tasks.
Another article in physorg, “Nearly half of all enzymes require metals to function in catalysing biological reactions” such as photosynthesis, metabolism, and respiration. Kylie Vincent, of Oxford University’s Department of Chemistry, continued: “Both the metal and the surrounding protein are crucial in tuning the reactivity of metal catalytic centres in enzymes.” Oxford is keen on watching how metallic enzymes work in order to imitate them. “There is much that we can learn,” Kylie said.
This could open the door for green fuel cells and other inventions may come from a better understanding of these amazing strings of amino acids that fold ever-so-precisely into the most efficient molecular machines ever witnessed! The various research makes no mention of evolution, they would have a difficult time anyway with this one, for example, why would natural selection create a specialized multi-part precision folding machine like GroEL+GroES, when other mechanisms already exist?
This is not a creation with no propose or direction or thought, rather an intelligently made by God which is driven with purpose and designed with specialized parts that is irreducibly complex!